The discovery of antibiotics is one of the greatest medical breakthroughs in the treatment of bacteremia. Although they are highly effective; inappropriate, or overuse has led to antibiotic resistance. An alternative approach is to develop antivirulence therapies that interfere with bacterial virulence determinants (e.g., toxins) and/or pathways that mediate virulence that would less likely promote the development of antibiotic resistance. One of the pivotal characteristics of an antivirulence compound is that the compound does not affect bacterial viability. Hence, this strategy ensures the preservation of the host endogenous microflora population. Bacteria causes infections by the secretion of bacterial toxins similar…